Publications

Selected Publications

(Corresponding Author)

Cohn RL, Gasek NS, Kuchel GA, Xu M.* “The heterogeneity of cellular senescence: insights at the single-cell level.” Trends Cell Biol 2022 May 20:S0962-8924(22)00116-7.

Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGP, Palmer AK, Inman CL, Barber LS, Al-Naggar IM, Zhou Y, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M.* “Targeting p21Cip1-Highly-Expressing Cells in Adipose Tissue Alleviates Insulin Resistance in Obesity” Cell Metabolism 2022 Jan 4;34(1):75-89.e8.

Gasek NS, Kuchel GA, Kirkland JL, Xu M.* “Strategies for Targeting Senescent Cells in Human Disease” Nature Aging 2021; 1 (10), 870-879

Wang B, Wang L, Gasek NS, Zhou Y, Kim T, Guo C, Jellison ER, Haynes L, Yadav S, Tchkonia T, Kuchel GA, Kirkland JL, Xu M.* “An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo” Nature Aging 2021; 1 (10), 962-973

Zhou Y, Xin X, Wang L, Wang B, Chen L, Liu O, Rowe DW, Xu M. “Senolytics improve the in vivo bone forming potential of bone marrow mesenchymal stem cells obtained from aged mice.” npj Regeneration Medicine, 2021 Jun 11;6(1):34.

Zhou Y, Al-Naggar IM, Chen PJ, Gasek NS, Wang K, Mehta S, Kuchel GA, Yadav S, Xu M. “Senolytics alleviate the degenerative disorders of temporomandibular joint in old age.” Aging Cell, 2021 Jun 8:e13394. doi: 10.1111/acel.13394.

Wang B, Liu Z, Chen VP, Wang L, Inman CL, Guo C, Zhou Y, Tchkonia T, Rowe DW, Kuchel GA, Robson P, Kirkland JL, Xu M. “Transplanting Cells from Old but Not Young Donors Causes Physical Dysfunction in Older Recipients.” Aging Cell 2020 Mar;19(3):e13106.

Xu M#, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik M, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi GPL, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T#, Kirkland JL#. “Senolytics Improve Physical Function and Increase Lifespan in Old Age.” Nature Medicine 2018 Aug;24(8):1246-1256.

(First Author)

Palmer AK*, Xu M*, Zhu Y*, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL. “Targeting senescent cells alleviates obesity-induced metabolic dysfunction.” Aging Cell. 2019 Mar 25:e12950. PMCID: PMC6516193 *, co-1st author

Farr JN*, Xu M*, Weivoda MM*, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir J, Ogrodnik M, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo R, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S. “Causal Role of Senescent Cells in Mediating Age-Related Bone Loss.” Nature Medicine 2017 Sep;23(9):1072-1079. PMCID: PMC5657592 *, co-1st author

Xu M, Bradley EW, Weivoda MM, Hwang SM, Pirtskhalava T, Decklever T, Curran GL, Ogrodnik M, Jurk D, Johnson KO, Lowe V, Tchkonia T, Westendorf JJ, Kirkland JL. “Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.” J Gerontol A Biol Sci Med Sci. 2016 Aug 10. pii: glw154. PMCID: PMC5861939

Xu M*, Palmer AK*, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL. “Targeting senescent cells enhances adipogenesis and metabolic function in old age.” Elife 2015 Dec 19;4. pii: e12997. PMCID: PMC4758946 *, co-1st author

Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. “JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.” Proc. Natl. Acad. Sci. (USA) 2015 Nov17;112(46):E6301-10.

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